HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → HCID 86669202, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | HOAt | HCID 181649 | — |
| Reactant | 3-Amino-6-bromopicolinic acid | HCID 45480452 | — |
| Reactant | 6-(3-aminopyridin-4-yl)-N,N-di-BOC-2-(methylthio)pyrimidin-4-amine | HCID 69044381 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86669202 | HCID 86669202 | 30% |
Reaction Steps
Method 27 was followed using 6-(3-aminopyridin-4-yl)-N,N-di-BOC-2-(methylthio)pyrimidin-4-amine (1.0 equiv.), 3-amino-6-bromopicolinic acid (1.0 equiv), EDC (1.0 equiv.), and HOAt (1.0 equiv.) in DMF yielding 3-amino-6-bromo-N-(4-(6-(di-BOC-amino)-2-(methylthio)pyrimidin-4-yl)pyridin-3-yl)picolinamide in 30% yield. LCMS (m/z): 632.1/634.0 (MH+); LC Rt=4.55 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-c17ceef0800c4941b5fd6acfc16fbf6d |
| Source note | uspto-grants-2014_09 |