HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → 3-amino-6-bromo-N-(4-(2-(di-BOC-amino)-6-methylpyrimidin-4-yl)pyridin-3-yl)picolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | HOAt | HCID 181649 | — |
| Reactant | 3-Amino-6-bromopicolinic acid | HCID 45480452 | — |
| Reactant | HCID 69047258 | HCID 69047258 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-amino-6-bromo-N-(4-(2-(di-BOC-amino)-6-methylpyrimidin-4-yl)pyridin-3-yl)picolinamide | HCID 86669203 | 12% |
Reaction Steps
Method 27 was followed using 4-(3-aminopyridin-4-yl)-N,N-di-BOC-6-methylpyrimidin-2-amine (1.0 equiv.), 3-amino-6-bromopicolinic acid (1.0 equiv), EDC (1.0 equiv.), and HOAt (1.0 equiv.) in DMF yielding 3-amino-6-bromo-N-(4-(2-(di-BOC-amino)-6-methylpyrimidin-4-yl)pyridin-3-yl)picolinamide in 12% yield. LCMS (m/z): 602.2 (MH+); LC Rt=3.60 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-96d1e4fb1e8d4ab29237b855cbf960b3 |
| Source note | uspto-grants-2014_09 |