Dichloromethane → 5-chloro-4-(4-chloro-1-methylpyrazol-5-yl)-N-[1-(1,3-dioxoisoindol-2-yl)-3-[2-(trifluoromethyl)phenyl]propan-2-yl]furan-2-carboxamide

HRID 699580Notes

Reaction equation

HRID 699580 reaction equation
[Br:49][P+:50]([N:51]1[CH2:52][CH2:53][CH2:54][CH2:55]1)([N:56]1[CH2:57][CH2:58][CH2:59][CH2:60]1)[N:61]1[CH2:62][CH2:63][CH2:64][CH2:65]1.[Cl:1][c:2]1[c:3](-[c:10]2[c:11]([Cl:16])[cH:12][n:13][n:14]2[CH3:15])[cH:4][c:5]([C:7](=[O:8])[OH:9])[o:6]1.[Cl:66][CH2:67][Cl:68].[NH2:17][CH:18]([CH2:19][N:20]1[C:21](=[O:30])[c:22]2[cH:23][cH:24][cH:25][cH:26][c:27]2[C:28]1=[O:29])[CH2:31][c:32]1[c:33]([C:38]([F:39])([F:40])[F:41])[cH:34][cH:35][cH:36][cH:37]1.[P-:42]([F:43])([F:44])([F:45])([F:46])([F:47])[F:48]>>[Cl:1][c:2]1[c:3](-[c:10]2[c:11]([Cl:16])[cH:12][n:13][n:14]2[CH3:15])[cH:4][c:5]([C:7](=[O:9])[NH:17][CH:18]([CH2:19][N:20]2[C:21](=[O:30])[c:22]3[cH:23][cH:24][cH:25][cH:26][c:27]3[C:28]2=[O:29])[CH2:31][c:32]2[c:33]([C:38]([F:39])([F:40])[F:41])[cH:34][cH:35][cH:36][cH:37]2)[o:6]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 9886HexafluorophosphateHCID 2733180Bromotripyrrolidin-1-ylphosphoniumHCID 578264792-Furancarboxylic acid, 5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-HCID 1785107622-[2-amino-3-[2-(trifluoromethyl)phenyl]propyl]isoindole-1,3-dione

Product 1

HCID 765764795-chloro-4-(4-chloro-1-methylpyrazol-5-yl)-N-[1-(1,3-dioxoisoindol-2-yl)-3-[2-(trifluoromethyl)phenyl]propan-2-yl]furan-2-carboxamide

Sources & evidence

ORD record
ord-6d32d15d2cac45c5b6d5cd68ba688db0
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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