HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 69972Generated: October 28, 2026
Potassium Carbonate → 4-Chloro-6-ethylpyridin-2-amine
https://huagongshe.com/reaction/69972
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Amino-4,6-dichloropyridine | HCID 5316649 | — |
| Reactant | HCID 178418750 | HCID 178418750 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Chloro-6-ethylpyridin-2-amine | HCID 69043369 | 33% |
Reaction Steps
To a solution of 4,6-dichloropyridin-2-amine (1.0 equiv.) in THF (0.1M) was added Pd(dppf)Cl2-DCM (0.1M), K2CO3 (3.0 equiv.), and Et2Zn (1.2 equiv.). The reaction was heated to 70° C. for 18 hrs. Upon cooling to room temperature, NH4Cl(sat.) was added, the mixture was extracted with EtOAc, dried with Na2SO4, and concentrated. The crude material was purified via SiO2 column chromatography eluting with DCM/MeOH (2%) to yield 4-chloro-6-ethylpyridin-2-amine in 33% yield. LCMS (m/z): 157.1 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08822497B2 |
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| Source dataset | uspto-grants-2014_09 |
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| ORD ID | ord-a0266f5e87fd437b9ef457e73767b91a |
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| Source note | uspto-grants-2014_09 |
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