HuagongsheHuagongshe Chemistry Print Report · For research reference only
Di-tert-butyl dicarbonate → 4-Chloro-6-ethyl-n,n-di-boc-pyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Di-tert-butyl dicarbonate | HCID 90495 | — |
| Reactant | 4-Chloro-6-ethylpyridin-2-amine | HCID 69043369 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-Chloro-6-ethyl-n,n-di-boc-pyridin-2-amine | HCID 69043108 | 27% |
Reaction Steps
Method 24 was followed using 4-chloro-6-ethylpyridin-2-amine (1.0 equiv.), BOC2O (2.0 equiv.), and DMAP (cat.) in DCM to yield 4-chloro-6-ethyl-N,N-di-BOC-pyridin-2-amine (27% yield). LCMS (m/z): 357.1 (MH+); LC Rt=4.11 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822497B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-7d55508c5c474540993a2048df4861e7 |
| Source note | uspto-grants-2014_09 |