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HRID69977

反应详情

EQUATION

反应方程式

HRID 69977 的结构方程式

REACTANTS

反应物

2
结构：Nc1cc(F)c(Br)nc1C(=O)O
HCID72698879

3-Amino-6-bromo-5-fluoro-2-pyridinecarboxylic acid

C6H4BrFN2O2

结构：CC(C)(C)OC(=O)NC1CN(c2ccncc2N)CCC1F
HCID76773287

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N[C@H]1CCCN(c2ccncc2NC(=O)c2nc(Br)c(F)cc2N)C1
HCID86669209

未命名化合物

收率 40%

PROCEDURE

实验过程

Following Method 11 of Example 305, (+/−)-tert-butyl 1-(3-aminopyridin-4-yl)-4-fluoropiperidin-3-ylcarbamate and 3-amino-6-bromo-5-fluoro-picolinic acid were reacted yielding (S)-tert-butyl 1-(3-(3-amino-6-bromo-5-fluoro-picolinamido)pyridin-4-yl)piperidin-3-ylcarbamate (40%). LCMS (m/z): 509.0 (MH+), LC Rt=3.04 min.

WORKUP

后处理

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