4-Chloro-3-nitropyridine → HCID 131729688, compound

HRID 69991Notes

Reaction equation

HRID 69991 reaction equation
[F:1][CH2:2][C@H:3]1[CH2:8][NH:7][CH2:6][C@@H:5]([NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH2:4]1.Cl[C:18]1[CH:23]=[CH:22][N:21]=[CH:20][C:19]=1[N+:24]([O-:26])=[O:25]>>[F:1][CH2:2][C@H:3]1[CH2:8][N:7]([C:18]2[CH:23]=[CH:22][N:21]=[CH:20][C:19]=2[N+:24]([O-:26])=[O:25])[CH2:6][C@@H:5]([NH:9][C:10](=[O:16])[O:11][C:12]([CH3:13])([CH3:15])[CH3:14])[CH2:4]1

Participants

3

Reactant 2

HCID 27357814-Chloro-3-nitropyridineHCID 130916753HCID 130916753, compound

Product 1

HCID 131729688HCID 131729688, compound

Procedure

Method 1 of Example 1 was followed using cis (+/−)-tert-butyl 5-(fluoromethyl)piperidin-3-ylcarbamate and 4-chloro-3-nitropyridine yielding cis (+/−)-tert-butyl 5-(fluoromethyl)-1-(3-nitropyridin-4-yl)piperidin-3-ylcarbamate. LCMS (m/z): 355.1 (MH+); LC Rt=2.41 min.

Sources & evidence

ORD record
ord-47299674b5754f1796c53c7441e8a4f2
Source dataset
uspto-grants-2014_09
Patent number
US08822497B2

Reaction notes

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