N-Iodosuccinimide → HCID 89645354, compound

Participants

Reaction Steps

However, the use of these reagents as source of iodine for reactions of iodo-de-carboxylation are limited. Reaction of N-halosuccinimides with aryl acrylic and aryl propiolic acids gives 1-halo-2-aryl-1-alkenes and 1-halo-2-aryl-1-alkynes (J. Org. Chem. 2002, v. 67, 7861; J. Org. Chem. 1999, v. 64, 6896; J. Org. Chem. 1997, v. 62, 199; Tetrahedron 2000, v. 56, 1369). All the reactions occur in the presence of catalyst. Reaction of α-(cyclopropylsulfonyl)phenylacetic acid with NIS gives α-iodobenzyl cyclopropyl sulfone only with 32% yield (J. Org. Chem. 1974, v. 39, 2516).

Provenance & Evidence