HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl bromopyruvate → (2-((4-Chlorophenyl)amino)thiazol-4-yl)(3,4,5-trimethoxyphenyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl bromopyruvate | HCID 66144 | — |
| Reactant | Thourea, (4-chlorophenyl)- (9CI) | HCID 735843 | — |
| Reactant | HCID 53361717 | HCID 53361717 | — |
| Product | (2-((4-Chlorophenyl)amino)thiazol-4-yl)(3,4,5-trimethoxyphenyl)methanone | HCID 56846908 | — |
Reaction Steps
(2-((4-Chlorophenyl)amino)thiazol-4-yl)(3,4,5-trimethoxyphenyl)methanone (5d) was prepared using the same method as used for 5a from 1-(4-chlorophenyl)thiourea and ethyl bromopyruvate. Melting point: 165-166° C. 1H NMR (500 MHz, CDCl3) δ 7.60 (s, br, 1H), 7.56 (s, 1H), 7.47 (s, 2H), 7.38 (d, 2H), 7.31 (d, 2H), 3.94 (s, 3H), 3.89 (s, 6H). MS: 402.9 (M−1)−; 427.0 (M+Na)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822513B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-7fb45943432944fc9a8a4ed596afc504 |
| Source note | uspto-grants-2014_09 |