反应详情

To a solution of (1-(phenylsulfonyl)-2-(1-(phenylsulfonyl)-2-(3,4,5-trimethoxybenzoyl)-1H-indol-5-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone (16xaa) (1 mmol) in ethanol (20 mL) was added sodium hydroxide (10 equiv) and stirred overnight in darkness. The reaction mixture was diluted by 50 mL of water and extracted by ethyl acetate (250 mL). The organic layer was dried over magnesium sulfate and concentrated. The residue was purified by flash column chromatography (hexane:ethyl acetate 3:1) or recrystallized from water and methanol to give a white solid. Yield: 30-95%.

1. extractionextracted by ethyl acetate (250 mL)
2. dry with materialThe organic layer was dried over magnesium sulfate
3. concentrationconcentrated
4. customThe residue was purified by flash column chromatography (hexane:ethyl acetate 3:1)
5. customrecrystallized from water and methanol
6. customto give a white solid