HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 70086Generated: October 25, 2026
Water → (R)-2-(2-chloro-6,7-dihydro-thieno[3,2-d]pyrimidin-4-ylamino)-3-methyl-butyramide
https://huagongshe.com/reaction/70086
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine | HCID 45789967 | — |
| Reactant | (2R)-2-amino-3-methylbutanamide hydrochloride | HCID 53486046 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (R)-2-(2-chloro-6,7-dihydro-thieno[3,2-d]pyrimidin-4-ylamino)-3-methyl-butyramide | HCID 59708380 | 74% |
Reaction Steps
800 mg 2,4-dichloro-6,7-dihydro-thieno[3,2-d]pyrimidine and 800 mg D-valinamide hydrochloride are placed in 8 ml dioxane, then 2.7 ml diisopropylethylamine are added. The reaction mixture is heated to 120° C. in the microwave for 2 hours. The residue is mixed with water. The precipitate formed is suction filtered and dried. 820 mg of the product are obtained as a powder Analytical HPLC (method R): RT=2.64 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08822474B2 |
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| Source dataset | uspto-grants-2014_09 |
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| ORD ID | ord-71d8978c174343739491a48a4e6cd835 |
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| Source note | uspto-grants-2014_09 |
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