HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Chloride → (S)-5-dibenzylamino-1-methylpiperidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | (S)-5-dibenzylaminopiperidin-2-one | HCID 10780155 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (S)-5-dibenzylamino-1-methylpiperidin-2-one | HCID 59708472 | 93.6% |
Reaction Steps
500 mg (S)-5-dibenzylamino-piperidin-2-one are suspended in 15 ml of tetrahydrofuran. While cooling with the ice bath 175 mg potassium-tert-butoxide are added. The reaction mixture is then stirred for 30 minutes at ambient temperature. While cooling with the ice bath 95 μl methyliodide are added. The reaction mixture is then stirred for 48 hours at ambient temperature and then combined with a saturated NaCl solution and ethyl acetate. The organic phase is dried and evaporated to dryness. 450 mg of the product are obtained as an oil. Analytical HPLC-MS (method D): RT=−1.07 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822474B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-05256a8dec414cdf9dff0971673b1bdf |
| Source note | uspto-grants-2014_09 |