Methylhydrazine → HCID 178481866, compound

HRID 70105Notes

Reaction equation

HRID 70105 reaction equation
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[N:3]1[CH2:12][C:13](=O)[CH2:14][C:15]([O:17]C)=O.[CH3:20][NH:21][NH2:22]>C(O)C>[OH:17][C:15]1[N:21]([CH3:20])[N:22]=[C:13]([CH2:12][N:3]2[C:2](=[O:1])[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[C:4]2=[O:11])[CH:14]=1

Participants

4

Reactant 2

HCID 6061MethylhydrazineHCID 2841582Methyl 3-oxo-4-phthalimidobutyrate

Product 1

HCID 178481866HCID 178481866, compoundYield 80.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10.0 g methyl 4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-oxo-butyrate are dissolved at 60° C. in 200 ml of ethanol and 1.94 g methylhydrazine are added. The reaction mixture is cooled and stirred further at ambient temperature. After 5 hours the precipitated substance is suction filtered and washed with ethanol. 7.91 g of the product are obtained as a powder.

Workup

  1. temperatureThe reaction mixture is cooled
  2. filtrationsuction filtered
  3. washwashed with ethanol

Sources & evidence

ORD record
ord-45305e1b2ad24486a496884471a401a0
Source dataset
uspto-grants-2014_09
Patent number
US08822474B2

Reaction notes

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