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HRID70109

反应详情

EQUATION

反应方程式

HRID 70109 的结构方程式

REACTANTS

反应物

3
结构：CO
HCID887

Methanol

CH4O

结构：O=S(=O)(O)O
HCID1118

Sulfuric acid

H2O4S

结构：CC(C)(C)OC(=O)N1C[C@H](NC(=O)OCC2c3ccccc3-c3ccccc32)C[C@H]1C(=O)[O-]
HCID25806067

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@@H]1C[C@@H](NC(=O)OCC2c3ccccc3-c3ccccc32)CN1.O=S(=O)(O)O
HCID66736107

未命名化合物

PROCEDURE

实验过程

850 mg 1-tert.butyl (2S,4R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2-dicarboxylate and 60 μl sulphuric acid are placed in 12 ml abs. methanol. The reaction mixture is then refluxed for 48 hours with stirring and then evaporated to dryness. 1.0 g product is obtained as a foam. Analytical HPLC-MS (method B): RT=1.80 min.

WORKUP

后处理

  1. temperatureThe reaction mixture is then refluxed for 48 hours
  2. customevaporated to dryness