8-Amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one → 8-[5-Chloro-4-(2-fluoro-6-methanesulfonyl-phenylamino)-pyrimidin-2-ylamino]-1,3,4,5-tetrahydro-1-benzazepin-2-one

HRID 701992Notes

Reaction equation

HRID 701992 reaction equation
[Cl:14][c:15]1[n:16][cH:17][c:18]([Cl:33])[c:19]([NH:21][c:22]2[c:23]([F:32])[cH:24][cH:25][cH:26][c:27]2[S:28](=[O:29])(=[O:30])[CH3:31])[n:20]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:13]1)[NH:7][C:8](=[O:12])[CH2:9][CH2:10][CH2:11]2>>[NH:1]([c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:13]1)[NH:7][C:8](=[O:12])[CH2:9][CH2:10][CH2:11]2)[c:15]1[n:16][cH:17][c:18]([Cl:33])[c:19]([NH:21][c:22]2[c:23]([F:32])[cH:24][cH:25][cH:26][c:27]2[S:28](=[O:29])(=[O:30])[CH3:31])[n:20]1

Participants

3

Reactant 2

HCID 46151688-Amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-oneHCID 86633988(2,5-Dichloro-pyrimidin-4-yl)-(2-fluoro-6-methanesulfonyl-phenyl)-amine

Product 1

HCID 672642088-[5-Chloro-4-(2-fluoro-6-methanesulfonyl-phenylamino)-pyrimidin-2-ylamino]-1,3,4,5-tetrahydro-1-benzazepin-2-one

Sources & evidence

ORD record
ord-c5694246ce0a472f9b0a0dab10a34634
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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