Hydrochloric Acid → 2-(2-(Pyridin-3-yl)ethyl)-n-p-tolylpiperazine-1-carboxamide dihydrochloride

Participants

Reaction Steps

4 M HCl in 1,4-dioxane (6 mL, 24 mmol) was added to tert-butyl 3-(2-(pyridin-3-yl)ethyl)-4-(p-tolylcarbamoyl)piperazine-1-carboxylate TFA salt (133.9 mg, 0.248 mmol). After 1 h, the reaction mixture was concentrated under reduced pressure, yielding 89.3 mg (90%) of the desired product as a white solid. LC-MS: RT=3.16 min, [M+H]+=325.2.

Provenance & Evidence