Potassium Cation → N-(4-chloro-3-(pyridin-2-ylamino)phenyl)-6-(trifluoromethyl)-2-methylpyridine-3-carboxamide

HRID 702370Notes

Reaction equation

HRID 702370 reaction equation
[CH3:30][C:31]([CH3:32])([O-:33])[CH3:34].[CH3:36][c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1.[Cl:1][c:2]1[c:3]([I:22])[cH:4][c:5]([NH:8][C:9](=[O:10])[c:11]2[c:12]([CH3:21])[n:13][c:14]([C:17]([F:18])([F:19])[F:20])[cH:15][cH:16]2)[cH:6][cH:7]1.[Fe+2:135].[K+:35].[NH2:23][c:24]1[n:25][cH:26][cH:27][cH:28][cH:29]1.[O:45]=[C:46]([CH:47]=[CH:48][c:49]1[cH:50][cH:51][cH:52][cH:53][cH:54]1)[CH:55]=[CH:56][c:57]1[cH:58][cH:59][cH:60][cH:61][cH:62]1.[O:63]=[C:64]([CH:65]=[CH:66][c:67]1[cH:68][cH:69][cH:70][cH:71][cH:72]1)[CH:73]=[CH:74][c:75]1[cH:76][cH:77][cH:78][cH:79][cH:80]1.[O:81]=[C:82]([CH:83]=[CH:84][c:85]1[cH:86][cH:87][cH:88][cH:89][cH:90]1)[CH:91]=[CH:92][c:93]1[cH:94][cH:95][cH:96][cH:97][cH:98]1.[Pd:43].[Pd:44].[cH:117]1[cH:118][cH:119][c:120]([P:121]([c:122]2[cH:123][cH:124][cH:125][cH:126][cH:127]2)[c-:128]2[cH:129][cH:130][cH:131][cH:132]2)[cH:133][cH:134]1.[cH:99]1[cH:100][cH:101][c:102]([P:103]([c:104]2[cH:105][cH:106][cH:107][cH:108][cH:109]2)[c-:110]2[cH:111][cH:112][cH:113][cH:114]2)[cH:115][cH:116]1>>[Cl:1][c:2]1[c:3]([NH:23][c:24]2[n:25][cH:26][cH:27][cH:28][cH:29]2)[cH:4][c:5]([NH:8][C:9](=[O:10])[c:11]2[c:12]([CH3:21])[n:13][c:14]([C:17]([F:18])([F:19])[F:20])[cH:15][cH:16]2)[cH:6][cH:7]1

Participants

10

Reactant 9

HCID 813Potassium CationHCID 1140TolueneHCID 104392-AminopyridineHCID 23938Palladium2×HCID 27284Ferrous cationHCID 95417Dibenzylidene acetone3×HCID 45749132-Methylpropan-2-olateHCID 66877122N-(4-Chloro-3-iodophenyl)-6-(trifluoromethyl)-2-methylpyridine-3-carboxamideHCID 178420532HCID 178420532, compound2×

Product 1

HCID 58614822N-(4-chloro-3-(pyridin-2-ylamino)phenyl)-6-(trifluoromethyl)-2-methylpyridine-3-carboxamide

Sources & evidence

ORD record
ord-79c9810d59ea48b192179895812a33e5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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