反应详情

cis-2-Aminocycloheptanecarboxylic acid methyl ester (1.65 g, 9.64 mmol) was treated with 20 mL of NH4OH/H2O and stirred at room temperature for 24 h. The solution was concentrated in vacuo and azeotroped once with toluene. The reaction afforded 2.20 g of cis-2-aminocycloheptanecarboxylic acid amide as a white solid: 1H NMR (DMSO-d6) δ 7.81 (m, 3 H), 7.20 (s, 1 H), 2.76 (m, 1 H), 1.68–1.40 (m, 11 H); MS m/e 157.28 (M+H)+.

1. concentrationThe solution was concentrated in vacuo
2. customazeotroped once with toluene