4,7-Dichloroquinazoline → 4-(4-Chlorophenyl)-1-[1-(7-chloroquinazolin-4-yl)-4-hydroxypyrrolidin-3-yl]piperidin-4-ol

HRID 702584Notes

Reaction equation

HRID 702584 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([OH:20])[CH2:9][CH2:10][N:11]([CH:14]3[CH2:15][NH:16][CH2:17][CH:18]3[OH:19])[CH2:12][CH2:13]2)[cH:6][cH:7]1.[Cl:21][c:22]1[n:23][cH:24][n:25][c:26]2[cH:27][c:28]([Cl:32])[cH:29][cH:30][c:31]12>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([OH:20])[CH2:9][CH2:10][N:11]([CH:14]3[CH2:15][N:16]([c:22]4[n:23][cH:24][n:25][c:26]5[cH:27][c:28]([Cl:32])[cH:29][cH:30][c:31]45)[CH2:17][CH:18]3[OH:19])[CH2:12][CH2:13]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 2418814,7-DichloroquinazolineHCID 669679644-(4-Chlorophenyl)-1-(4-hydroxy-pyrrolidin-3-yl)-piperidin-4-ol

Product 1

HCID 584511444-(4-Chlorophenyl)-1-[1-(7-chloroquinazolin-4-yl)-4-hydroxypyrrolidin-3-yl]piperidin-4-ol

Sources & evidence

ORD record
ord-ceb500eda48a4260830c19bd6a314aa5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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