Acetic Acid → 6-Bromo-4-(2,5-difluorobenzyl)-1,2,3,4-tetrahydro-[1,8]naphthyridine
Reaction equation
[Br:20][N:21]1[C:22](=[O:23])[CH2:24][CH2:25][C:26]1=[O:27].[CH3:31][C:32](=[O:33])[OH:34].[Cl:28][CH2:29][Cl:30].[F:1][c:2]1[c:3]([CH2:4][CH:5]2[CH2:6][CH2:7][NH:8][c:9]3[n:10][cH:11][cH:12][cH:13][c:14]32)[cH:15][c:16]([F:19])[cH:17][cH:18]1>>[F:1][c:2]1[c:3]([CH2:4][CH:5]2[CH2:6][CH2:7][NH:8][c:9]3[n:10][cH:11][c:12]([Br:20])[cH:13][c:14]32)[cH:15][c:16]([F:19])[cH:17][cH:18]1Participants
5
Sources & evidence
- ORD record
- ord-5e7a96d241e340f7946f7b710550ab3d
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
Loading…