Dichloromethane → 5-Bromo-1-methyl-3-(5-(1-methylpiperidin-4-yl)pyridin-2-ylamino)pyridin-2(1H)-one
Reaction equation
[Br:15][c:16]1[c:17](=[O:24])[n:18]([CH3:23])[cH:19][c:20]([Br:22])[cH:21]1.[C:25](=[O:26])([O-:27])[O-:28].[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([c:8]2[cH:9][cH:10][c:11]([NH2:14])[n:12][cH:13]2)[CH2:6][CH2:7]1.[Cl:93][CH2:94][Cl:95].[Cs+:29].[Cs+:30].[O:31]1[CH2:32][CH2:33][O:34][CH2:35][CH2:36]1.[O:39]=[C:40]([CH:41]=[CH:42][c:43]1[cH:44][cH:45][cH:46][cH:47][cH:48]1)[CH:49]=[CH:50][c:51]1[cH:52][cH:53][cH:54][cH:55][cH:56]1.[O:57]=[C:58]([CH:59]=[CH:60][c:61]1[cH:62][cH:63][cH:64][cH:65][cH:66]1)[CH:67]=[CH:68][c:69]1[cH:70][cH:71][cH:72][cH:73][cH:74]1.[O:75]=[C:76]([CH:77]=[CH:78][c:79]1[cH:80][cH:81][cH:82][cH:83][cH:84]1)[CH:85]=[CH:86][c:87]1[cH:88][cH:89][cH:90][cH:91][cH:92]1.[Pd:37].[Pd:38]>>[CH3:1][N:2]1[CH2:3][CH2:4][CH:5]([c:8]2[cH:9][cH:10][c:11]([NH:14][c:16]3[c:17](=[O:24])[n:18]([CH3:23])[cH:19][c:20]([Br:22])[cH:21]3)[n:12][cH:13]2)[CH2:6][CH2:7]1Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-837107aed6cf4ffa9bf8559130ec30ad
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (3/10)
Reaction notes
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