HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 3-Bromo-5-chlorobenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 3-Bromo-5-chlorobenzoic acid | HCID 33128 | — |
| Reactant | Di-tert-butyl dicarbonate | HCID 90495 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-Bromo-5-chlorobenzamide | HCID 53417471 | — |
Reaction Steps
To a solution of 3-bromo-5-chlorobenzoic acid (2.88 g; 12.2 mmol; Note 1) and pyridine (1.04 mL; 12.8 mmol) in MeCN (100 mL) at room temperature was added (Boc)2O (3.47 g; 15.9 mmol) in one portion. The mixture was aged 30 min, (NH4)2CO3 was added in one portion.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08822518B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-5fd7fbd0c56e41619fe134cf08fc6fa0 |
| Source note | uspto-grants-2014_09 |