HCID 178467945, compound → 2-(3-Bromophenyl)-1H-imidazole

HRID 70291Notes

Reaction equation

HRID 70291 reaction equation
C(O[CH:4](OCC)[CH2:5][NH:6][C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([Br:15])[CH:10]=1)=[NH:8])C>C(O)=O>[Br:15][C:11]1[CH:10]=[C:9]([C:7]2[NH:8][CH:4]=[CH:5][N:6]=2)[CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 1

HCID 178467945HCID 178467945, compound

Product 1

HCID 529838842-(3-Bromophenyl)-1H-imidazole

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A solution of N-[2,2-bis(ethyloxy)ethyl]-3-bromobenzenecarboximidamide (2.85 g; 9.04 mmol; Step 2 above) in HCO2H (15 mL) was heated at 80° C. for 1 h and concentrated in vacuo (2×PhMe chase). The residue was purified by flash chromatography (MeOH/NH4OH/CH2Cl2), affording the title compound as a light pink solid. LC/MS (method A) tR 1.19 min, m/z 223, 225 (M+H, Br isotopes).

Workup

  1. concentrationconcentrated in vacuo (2×PhMe chase)
  2. customThe residue was purified by flash chromatography (MeOH/NH4OH/CH2Cl2)

Sources & evidence

ORD record
ord-85b10f3edb364e3b8baf334f9acb3999
Source dataset
uspto-grants-2014_09
Patent number
US08822518B2

Reaction notes

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