Pyridine → N-(3-Fluoro-4-(5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

HRID 703017Notes

Reaction equation

HRID 703017 reaction equation
[Cl:37][CH2:38][Cl:39].[F:1][c:2]1[cH:3][c:4]([NH2:19])[cH:5][cH:6][c:7]1[O:8][c:9]1[n:10][cH:11][n:12][n:13]2[c:14]1[c:15]([CH3:18])[cH:16][cH:17]2.[F:20][c:21]1[cH:22][cH:23][c:24](-[n:27]2[c:28](=[O:36])[c:29]([C:33](=[O:34])[Cl:35])[cH:30][cH:31][cH:32]2)[cH:25][cH:26]1.[cH:40]1[cH:41][cH:42][n:43][cH:44][cH:45]1>>[F:1][c:2]1[cH:3][c:4]([NH:19][C:33]([c:29]2[c:28](=[O:36])[n:27](-[c:24]3[cH:23][cH:22][c:21]([F:20])[cH:26][cH:25]3)[cH:32][cH:31][cH:30]2)=[O:34])[cH:5][cH:6][c:7]1[O:8][c:9]1[n:10][cH:11][n:12][n:13]2[c:14]1[c:15]([CH3:18])[cH:16][cH:17]2

Participants

5

Reactant 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 210816133-Fluoro-4-(5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yloxy)benzenamineHCID 596809561-(4-Fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonyl chloride

Product 1

HCID 16739700N-(3-Fluoro-4-(5-methylpyrrolo[2,1-f][1,2,4]triazin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Sources & evidence

ORD record
ord-327e5605e3bb44898014dc790e24f095
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (3/10)

Reaction notes

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