HuagongsheHuagongshe Chemistry Print Report · For research reference only
D-Psicose → Methyl 2-amino-4-(methylthio)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | D-Psicose | HCID 441036 | — |
| Reactant | 4-Methylsulfanyl-2-nitro-benzoic acid methyl ester | HCID 13988044 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Platinum sulfide (PtS) | HCID 82861 | — |
| Solvent | Methyl Acetate | HCID 6584 | — |
| Product | Methyl 2-amino-4-(methylthio)benzoate | HCID 13988045 | — |
Reaction Steps
A mixture of methyl 4-(methylthio)-2-nitrobenzoate (11.3 g. 49.7 mmol) and 5% platinum sulfide on carbon catalyst (0.7 g) in methyl acetate (40 mL) was hydrogenated at 750 Psi and 75° C. until hydrogen uptake ceased. The mixture was filtered through Celite®, and the filtrate solvent was rotary evaporated, leaving methyl 2-amino-4-(methylthio)benzoate as a slightly tan crystalline solid (8.7 g) melting at 57°-59° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04981509 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-d2456382c81b41cba50b4677bd80b183 |
| Source note | uspto-grants-1991_01 |