HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → Ethyl 3-bromomethyl-5-chloro-2-benzofurancarboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Ethyl 5-chloro-3-methylbenzofuran-2-carboxylate | HCID 15643819 | — |
| Catalyst | Benzoyl Peroxide | HCID 7187 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | Ethyl 3-bromomethyl-5-chloro-2-benzofurancarboxylate | HCID 15678689 | 76% |
Reaction Steps
A mixture of ethyl 5-chloro-3-methyl-2 -benzofurancarboxylate (52.5 g, 0.22 mol), N-bromosuccinimide (39.15 g, 0.22 mol) and benzoyl peroxide (0.4 g) in carbon tetrachloride (750 ml) was stirred and refluxed for 10 hours. The mixture was cooled, filtered and the filtrate was concentrated. The crude product was recrystallized from hexane to give 52.8 g (76%) of ethyl 3-bromomethyl-5-chloro-2-benzofurancarboxylate: mp 112-114° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04981849 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-d6ed634cb98242d48a6e4f97d0258e84 |
| Source note | uspto-grants-1991_01 |