反应详情

A mixture of ethyl 5-chloro-3-methylbenzo[b]thiophene-2-carboxylate (9.0 g, 0.035 mol), N-bromosuccinimide (6.53 g, 0.037 mol) and benzoyl peroxide (130 mg) in carbon tetrachloride (150 ml) was refluxed and illuminated with a sunlamp for 2 hours. The resulting suspension was cooled, filtered and the filter cake was triturated with methanol to give 9.9 g (85%) of the methanol insoluble ethyl 3-bromomethyl-5-chlorobenzo[b]thiophene-2-carboxylate: mp 148°-150° C.

1. temperaturewas refluxed
2. customilluminated with a sunlamp for 2 hours
3. temperatureThe resulting suspension was cooled
4. filtrationfiltered
5. customthe filter cake was triturated with methanol
6. customto give 9.9 g (85%) of the methanol insoluble ethyl 3-bromomethyl-5-chlorobenzo[b]thiophene-2-carboxylate