19404-18-3 → 3-(Bromomethyl)-5-chloro-1-benzothiophene

HRID 703066Notes

Reaction equation

HRID 703066 reaction equation
[Br:1][CH2:2][C:3]1[C:4]2[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:5]=2[S:6][C:7]=1C(OCC)=O.ClC1C=CC2SC=C(C)C=2C=1>>[Br:1][CH2:2][C:3]1[C:4]2[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:5]=2[S:6][CH:7]=1

Participants

3

Reactant 2

HCID 31731719404-18-3HCID 14836261Ethyl 3-Bromomethyl-5-chlorobenzo[b]thiophene-2-carboxylate

Product 1

HCID 27798573-(Bromomethyl)-5-chloro-1-benzothiopheneYield 57%

Procedure

Using the general procedure of Example 1, Method A, (iv), replacing ethyl-5-chloro-3-methylbenzo[b]thiophene-2-carboxylate with 5-chloro-3-methylbenzo[b]thiophene gave 2.78 g (57%) of 3-bromomethyl-5-chlorobenzo[b]thiophene: mp 126°-128° C.

Sources & evidence

ORD record
ord-83af5daa7af244ce9b16da5d27b431d8
Source dataset
uspto-grants-1991_01
Patent number
US04981848

Reaction notes

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