HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 5-Nitrothiazole-2-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 5-Nitrothiazole-2-carboxylic acid | HCID 14842275 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Nitrothiazole-2-carbonyl chloride | HCID 14842276 | — |
Reaction Steps
Oxalyl chloride (13 ml) was added dropwise to a stirred suspension of 5-nitrothiazole-2-carboxylic acid (12.9 g; Chem. Ber. 1973, 106, 722) in a mixture of methylene chloride (80 ml and dimethylformamide (20 ml). The mixture was stirred at laboratory temperature for 30 minutes and evaporated to dryness to give 5-nitrothiazole-2-carbonyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04981856 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-08e7790bd89648df9c280ceede9c8168 |
| Source note | uspto-grants-1991_01 |