Binap, (A+-)- → HCID 15034949, compound

Participants

Reaction Steps

In 100 ml-volume stainless steel autoclave whose atmosphere had been displaced with nitrogen was added a solution of 2.01 g (10 mmole) of ethyl 2-(N-acetylamino)methyl-3-oxobutanoate and 168 mg (0.1 mmole) of ##STR11## ((+)-BINAP) in 15 ml of methylene chloride, and a reaction was conducted at 70 ° C. under a hydrogen pressure of 130 kg/cm2 for 30 hours. The reaction mixture was concentrated, and the residue was purified by silica gel chromatography using a 7/3 (by volume) mixture of hexane and isopropanol as an eluent to give 1.7 g (yield: 85%) of ethyl (2S, 3R)-2-(N-acetylamino)methyl-3-hydroxybutanoate having an optical purity of 93 %ee as determined in the same manner as in Example 2.

Provenance & Evidence