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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 70331Generated: October 27, 2026

4-(1,3-Dioxolan-2-yl)-3-(trifluoromethyl)phenylboronic acid → 4'-(1,3-Dioxolan-2-yl)-3'-(trifluoromethyl)-3-biphenylcarboxamide

https://huagongshe.com/reaction/70331

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(1,3-Dioxolan-2-yl)-3-(trifluoromethyl)phenylboronic acidHCID 58276450—
Reactant3-Bromo-2-methylbenzamideHCID 58828877—
SolventToluene ethanolHCID 21863594—
Product4'-(1,3-Dioxolan-2-yl)-3'-(trifluoromethyl)-3-biphenylcarboxamideHCID 67159994—

Reaction Steps

The title compound was prepared from 3-bromo-2-methylbenzamide (Ex IV-2) and 4-(1,3-dioxolan-2-yl)-3-(trifluoromethyl)phenylboronic acid (I-IX-8) according to the procedure described in Example IX-10, using PhMe/EtOH (4:1) as organic colsovent. LC/MS (method A) 2.36 min; m/z 351 (M+H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08822518B2
Source datasetuspto-grants-2014_09
ORD IDord-06fa1576e20d482bbd562d2684de0f67
Source noteuspto-grants-2014_09