HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → N-[[[1-Azabicyclo[2.2.2]octan-3-yl]amino]carbonyl]-2-thiophenecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Quinuclidine, 3-amino-, dihydrochloride | HCID 197853 | — |
| Reactant | N-(Aminocarbonyl)-2-thiophenecarboxamide | HCID 395032 | — |
| Reactant | Maleate(2-) | HCID 5288227 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-[[[1-Azabicyclo[2.2.2]octan-3-yl]amino]carbonyl]-2-thiophenecarboxamide | HCID 15616403 | — |
Reaction Steps
The above compound was prepared, following the procedure of Example 14b, from 3-aminoquinuclidine dihydrochloride (1.0 g, 5 mmol), 2-thienoylurea (0.85 g, 5 mmol) and diisopropylethylamine (1.3 g, 10 mmol) in pyridine (20 ml). The product (0.79 g) was converted to hydrochloride half hydrate, mp 232°-233° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04983600 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-f5c9b0a985694562aec02036d1803a0f |
| Source note | uspto-grants-1991_01 |