3-Aminoquinuclidine → HCID 15616404, compound

HRID 703417Notes

Reaction equation

HRID 703417 reaction equation
[NH2:1][CH:2]1[CH:7]2[CH2:8][CH2:9][N:4]([CH2:5][CH2:6]2)[CH2:3]1.[F:10][C:11]1[CH:21]=[CH:20][CH:19]=[CH:18][C:12]=1[C:13]([N:15]=[C:16]=[O:17])=[O:14].C([O-])(=O)CCC([O-])=O>>[N:4]12[CH2:9][CH2:8][CH:7]([CH2:6][CH2:5]1)[CH:2]([NH:1][C:16]([NH:15][C:13](=[O:14])[C:12]1[CH:18]=[CH:19][CH:20]=[CH:21][C:11]=1[F:10])=[O:17])[CH2:3]2

Participants

4

Reactant 3

HCID 1232383-AminoquinuclidineHCID 160419SuccinateHCID 130803922-Fluorobenzoyl isocyanate

Product 1

HCID 15616404HCID 15616404, compound

Procedure

The above compound was prepared, following the procedure of Example 1, from 3-aminoquinuclidine (0.63 g, 5 mmol) and crude 2-fluorobenzoyl isocyanate (1.3 g, ca 7 mmol). The product (1.35 g) was converted to the 1:1 succinate, mp 187°-188° C.

Workup

  1. customThe above compound was prepared

Sources & evidence

ORD record
ord-851df57165f04a84a160d2695cf9298e
Source dataset
uspto-grants-1991_01
Patent number
US04983600

Reaction notes

Loading…