Diisopropylethylamine → HCID 15616388, compound

Participants

Reaction Steps

The above compound was prepared, following the procedure of Example 14b, from 3-aminoquinuclidine dihydrochloride(1.0 g, 5 mmol), 2-pyridoylurea (0.82 g, 5 mmol) and di-isopropylethylamine (1.3 g, 10 mmol) in pyridine (20 ml) by refluxing for 4 days. The pyridine was evaporated and the residue partitioned between ether and 10% aqueous w/v citric acid. The mixture was filtered, the aqueous phase washed with ether, then basified with potassium carbonate to precipitate the title compound (0.60 g) which was converted to the 1:1 fumarate, mp 202°-203° C.

Provenance & Evidence