3-Aminoquinuclidine → HCID 15616389, compound

HRID 703422Notes

Reaction equation

HRID 703422 reaction equation
[NH2:1][CH:2]1[CH:7]2[CH2:8][CH2:9][N:4]([CH2:5][CH2:6]2)[CH2:3]1.[CH3:10][C:11]1[CH:21]=[CH:20][CH:19]=[CH:18][C:12]=1[C:13]([N:15]=[C:16]=[O:17])=[O:14].C([O-])(=O)/C=C/C([O-])=O>>[N:4]12[CH2:9][CH2:8][CH:7]([CH2:6][CH2:5]1)[CH:2]([NH:1][C:16]([NH:15][C:13](=[O:14])[C:12]1[CH:18]=[CH:19][CH:20]=[CH:21][C:11]=1[CH3:10])=[O:17])[CH2:3]2

Participants

4

Reactant 3

HCID 1232383-AminoquinuclidineHCID 5460307FumarateHCID 12259962Benzoyl isocyanate, 2-methyl-

Product 1

HCID 15616389HCID 15616389, compound

Procedure

The above compound was prepared, following the procedure of Example 1, from 3-aminoquinuclidine (0.63 g, 5 mmol) and crude 2-methylbenzoyl isocyanate (1.35 g, ca 7 mmol). The product (1.23 g) was converted to the 1:1 fumarate, mp 216°-217° C.

Workup

  1. customThe above compound was prepared

Sources & evidence

ORD record
ord-fc374b69e1544eb989a70bb455a1d80b
Source dataset
uspto-grants-1991_01
Patent number
US04983600

Reaction notes

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