Oxalate → N-[[[1-Azabicyclo[2.2.2]octan-3-yl]amino]carbonyl]-2-((cyclopropyl)methoxy)benzamide

HRID 703424Notes

Reaction equation

HRID 703424 reaction equation
[NH2:1][CH:2]1[CH:7]2[CH2:8][CH2:9][N:4]([CH2:5][CH2:6]2)[CH2:3]1.[CH:10]1([CH2:13][O:14][C:15]2[CH:23]=[CH:22][CH:21]=[CH:20][C:16]=2[C:17]([NH2:19])=[O:18])[CH2:12][CH2:11]1.C([O-])(=O)[C:25]([O-])=[O:26]>>[N:4]12[CH2:9][CH2:8][CH:7]([CH2:6][CH2:5]1)[CH:2]([NH:1][C:25]([NH:19][C:17](=[O:18])[C:16]1[CH:20]=[CH:21][CH:22]=[CH:23][C:15]=1[O:14][CH2:13][CH:10]1[CH2:12][CH2:11]1)=[O:26])[CH2:3]2

Participants

4

Reactant 3

HCID 71081OxalateHCID 1232383-AminoquinuclidineHCID 27280292-(Cyclopropylmethoxy)benzamide

Product 1

HCID 15616407N-[[[1-Azabicyclo[2.2.2]octan-3-yl]amino]carbonyl]-2-((cyclopropyl)methoxy)benzamide

Procedure

The above compound was prepared, following the procedure of Example 1, from 3-aminoquinuclidine (0.63 g, 5 mmol) and crude 2-((cyclopropyl)methoxy)benzamide (1.4 g, ca 5 mmol). The product was converted to the 1:1 oxalate, half hydrate mp 128°-131° C.

Workup

  1. customThe above compound was prepared

Sources & evidence

ORD record
ord-c47cb6a26f7041a9b70a8a6e276f303e
Source dataset
uspto-grants-1991_01
Patent number
US04983600

Reaction notes

Loading…