HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-quinuclidin-3-amine → (S)-N-[[[1-Azabicyclo[2.2.2]octan-3-yl]amino]carbonyl]-2-methoxybenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-quinuclidin-3-amine | HCID 719216 | — |
| Reactant | Fumarate | HCID 5460307 | — |
| Reactant | 2-Methoxybenzoyl isocyanate | HCID 14119328 | — |
| Product | (S)-N-[[[1-Azabicyclo[2.2.2]octan-3-yl]amino]carbonyl]-2-methoxybenzamide | HCID 15616384 | — |
Reaction Steps
The above compound was prepared, following the procedure of Example 1, from (S)-3-aminoquinuclidine (0.63 g, 5 mmol) and 2-methoxybenzoyl isocyanate (1.26 g, 7 mmol). The product (1.44 g) was converted to the 1:1 fumarate, mp 158°-159° C. (dec).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04983600 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-ab525d72d9d84d2d88df5f621b72d01b |
| Source note | uspto-grants-1991_01 |