Chloroform ether → 2-(3-chloropropyl)-6,7-dimethoxy-1(2H)-phthalazinone

HRID 703454Notes

Reaction equation

HRID 703454 reaction equation
O[CH2:2][CH2:3][N:4]1[N:13]=[CH:12][C:11]2[C:6](=[CH:7][C:8]([O:16][CH3:17])=[C:9]([O:14][CH3:15])[CH:10]=2)[C:5]1=[O:18].OCCCN1N=CC2C(=CC(OC)=C(OC)C=2)C1=O.[CH:38](Cl)(Cl)[Cl:39].C(OCC)C>>[Cl:39][CH2:38][CH2:2][CH2:3][N:4]1[N:13]=[CH:12][C:11]2[C:6](=[CH:7][C:8]([O:16][CH3:17])=[C:9]([O:14][CH3:15])[CH:10]=2)[C:5]1=[O:18]

Participants

4

Reactant 3

HCID 21911965Chloroform etherHCID 221501572-(2-hydroxyethyl)-6,7-dimethoxy-1(2H)-phthalazinoneHCID 221501672-(3-hydroxypropyl)-6,7-dimethoxy-1(2H)-phthalazinone

Product 1

HCID 221501712-(3-chloropropyl)-6,7-dimethoxy-1(2H)-phthalazinone

Procedure

Working as described in Example 2 but replacing 2-(2-hydroxyethyl)-6,7-dimethoxy-1(2H)-phthalazinone with an equivalent amount of 2-(3-hydroxypropyl)-6,7-dimethoxy-1(2H)-phthalazinone obtained as described in Example 12, 2-(3- chloropropyl)-6,7-dimethoxy-1(2H)-phthalazinone is obtained (m.p. 185°-187° C., from chloroform/ethyl ether).

Workup

  1. customobtained

Sources & evidence

ORD record
ord-e9750e8b6eba4551b11f64ca69604883
Source dataset
uspto-grants-1991_01
Patent number
US04983606

Reaction notes

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