HCID 10708388, compound → HCID 10729495, compound

Participants

Reaction Steps

To 100 ml ethanol, was added 10% Pd/C (1.2 g), MgO (1.0 g), and 6-chloro-N-(1H-indol-1-yl)-N-propyl-4-pyrimidinamine (4.2 g). After stirring under H2 at ambient temperature for three hours, the mixture was filtered, and the filtrate evaporated to 4.0 g of an oil. This material was eluted on a silica gel column with 10% ethyl acetate/DCM via HPLC, to give 2.4 g (66%) of an oil, product N-(1H-Indol-1-yl)-N-propyl-4-pyrimidinamine.

Provenance & Evidence