HCID 15158245, compound → HCID 15158247, compound

Participants

Reaction Steps

To a slurry of 10% Pd/C (1.0 g) and MgO (0.8 g) in 10 ml ethanol (100%) was added 6-chloro-N-propyl-N-(1H-pyrrol-1-y)-4-pyrimidinamine (4.9 g), in 90 ml ethanol (100%) and the mixture was hydrogenated under atmospheric pressure at room temperature for 6 hours. The mixture was filtered and the filtrate evaporated to yield 4.92 g of a solid which was eluted with 10% ethyl acetate/DCM on a silica gel column via flash method. The desired fractions were evaporated to yield 2.45 g (57.8%) of an oil, N-propyl-N-(1H-pyrrol-1-yl)-4-pyrimidinamine.

Provenance & Evidence