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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 703504Generated: October 31, 2026

5-(4-Fluorophenyl)thiophene-2-carboxylic acid → 2-Cyano-N-[5-(4-(1,1-dimethylethyl)phenyl)thien-2-yl]-3-hydroxybut-2-enamide

https://huagongshe.com/reaction/703504

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(4-Fluorophenyl)thiophene-2-carboxylic acidHCID 1873401—
ReactantHCID 67868252HCID 67868252—
Product2-Cyano-N-[5-(4-(1,1-dimethylethyl)phenyl)thien-2-yl]-3-hydroxybut-2-enamideHCID 67869649—

Reaction Steps

2-Cyano-N-[5-(4-fluorophenyl)thien-2-yl]-3-hydroxybut-2-enamide, m.p. 232°-234° C. (from 2-carboxy-5-(4-fluorophenyl)thiophene).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04983619
Source datasetuspto-grants-1991_01
ORD IDord-3796423922af4b71abd4410acfc6a153
Source noteuspto-grants-1991_01