Carbonic acid-guanidine (1:1) → HCID 22150373, compound

HRID 703509Notes

Reaction equation

HRID 703509 reaction equation
C(=O)(O)O.[NH2:5][C:6]([NH2:8])=[NH:7].CN([CH:12]=[CH:13][C:14]([C:16]1[CH:21]=[CH:20][C:19]([C:22]([CH3:25])([CH3:24])[CH3:23])=[CH:18][CH:17]=1)=O)C>C(O)C>[NH2:7][C:6]1[N:8]=[C:14]([C:16]2[CH:17]=[CH:18][C:19]([C:22]([CH3:25])([CH3:24])[CH3:23])=[CH:20][CH:21]=2)[CH:13]=[CH:12][N:5]=1

Participants

4

Reactant 2

HCID 286947Carbonic acid-guanidine (1:1)HCID 53954562HCID 53954562, compound

Product 1

HCID 22150373HCID 22150373, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Sodium metal (10.4 g) was added to absolute ethanol (40 ml). When all the sodium had dissolved, the sodium ethoxide solution so formed was added to a mixture of guanidine carbonate (1.56 g) and (1-(N,N-dimethylamino)-3-(4-(1,1-dimethylethyl) phenyl)prop-1-en-3-one (2.5 g) dissolved in absolute ethanol (40 ml) and the mixture heated under reflux with stirring overnight. The reaction was followed by tlc. On cooling the solid material formed was filtered and washed with water to remove Na2CO3 to give a white crystalline solid, m.p. 186° C.

Workup

  1. temperaturethe mixture heated
  2. temperatureunder reflux
  3. temperatureOn cooling the solid material
  4. customformed
  5. filtrationwas filtered
  6. washwashed with water
  7. customto remove Na2CO3
  8. customto give a white crystalline solid, m.p. 186° C.

Sources & evidence

ORD record
ord-9f4924f3dec84cd2a6e1669d77bf73c2
Source dataset
uspto-grants-1991_01
Patent number
US04983619

Reaction notes

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