反应详情

A mixture of 2-amino-4-chlorobenzenethiol (327 mg, 2.05 mmol), N,N-dimethylacrylamide (203 mg, 2.05 mmol) and HOAc (0.5 ml) in CH2Cl2 (5 ml) was stirred at room temperature for 3 days. The reaction was quenched with NaHCO3 (aq.) and then extracted with CH2Cl2 (2×10 ml). The organic layer was washed with water and brine and concentrated in vacuo. The crude product was purified by chromatography on silica gel (50% ethyl acetate in hexane) to yield the title compound (284 mg, 54%).

1. customThe reaction was quenched with NaHCO3 (aq.)
2. extractionextracted with CH2Cl2 (2×10 ml)
3. washThe organic layer was washed with water and brine
4. concentrationconcentrated in vacuo
5. customThe crude product was purified by chromatography on silica gel (50% ethyl acetate in hexane)