HCID 20986071, compound → HCID 14425930, compound

HRID 703527Notes

Reaction equation

HRID 703527 reaction equation
[N:1]1([CH2:7][CH2:8][O:9][C:10]2[CH:18]=[CH:17][C:13]([CH:14]=[N:15]O)=[CH:12][CH:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>N.[Ni]>[N:1]1([CH2:7][CH2:8][O:9][C:10]2[CH:11]=[CH:12][C:13]([CH2:14][NH2:15])=[CH:17][CH:18]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 20986071HCID 20986071, compound

Product 1

HCID 14425930HCID 14425930, compoundYield 90.9%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 222AmmoniaSolvent

Procedure

A suspension of 32.3 g of 4-(2-piperidinoethoxy)benzaldoxime in 400 ml of 10% methanolic ammonia was hydrogenated over 3.6 g of Raney nickel catalyst at a pressure of 50 kg/cm2 and at 30° C. The catalyst was filtered off and the filtrate was evaporated. The residue was distilled to give 27.7 g of colorless oil, b.p. 185°-190° C. (6 mmHg).

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated
  3. distillationThe residue was distilled

Sources & evidence

ORD record
ord-226d09f0646f48d19c88abf1af886329
Source dataset
uspto-grants-1991_01
Patent number
US04983633

Reaction notes

Loading…