HCID 54362778, compound → HCID 14049588, compound

HRID 703562Notes

Reaction equation

HRID 703562 reaction equation
[CH2:1]([O:10][C@@H:11]1[C@@H:15]([CH2:16][O:17]C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[O:14][C@@H:13]([N:37]2[CH:44]=[C:43]([F:45])[C:41](=[O:42])[NH:40][C:38]2=[O:39])[CH2:12]1)[CH:2]=[CH:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>CO.[C].[Pd]>[F:45][C:43]1[C:41](=[O:42])[NH:40][C:38](=[O:39])[N:37]([CH:44]=1)[C@@H:13]1[O:14][C@H:15]([CH2:16][OH:17])[C@@H:11]([O:10][CH2:1][CH2:2][CH2:3][C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:12]1

Participants

4

Reactant 1

HCID 54362778HCID 54362778, compound

Product 1

HCID 14049588HCID 14049588, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

To a solution of 500 mg of the 2'-deoxy-3'-O-cinnamyl-5-fluoro-5'-O-trityluridine prepared as the intermediate in Example 224 in 30 ml of methanol was added 50 mg of 5 % palladium-carbon, and the catalytic reduction was conducted at room temperature for 1 hour.

Sources & evidence

ORD record
ord-2bdc02d6048d4bcfbd4848d0f8656612
Source dataset
uspto-grants-1991_01
Patent number
US04983609

Reaction notes

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