Water → HCID 86744481, compound

Participants

Reaction Steps

A solution of 6.2 g of 6-chlorobicyclo[4.2.0]oct-2-en-7-one, prepared as shown in Preparation 7, and 3.4 g. of hydroxylamine hydrochloride in 30 ml of pyridine was stirred at 0° C. for 1 hour, then stirred overnight at room temperature. The mixture was poured into water and extracted with methylene chloride. The extract was washed with 0.5N hydrochloric acid followed by brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residual pyridine removed under high vacuum. The residue was dissolved in diethyl ether, filtered and solvent removed from the filtrate under reduced pressure, to give 6-chlorobicyclo[4.2.0]oct-2-en-7-one oxime, the compound of formula (6A) where Y is hydrogen, 5.4 g.

Provenance & Evidence