Water → HCID 22150552, compound

Participants

Reaction Steps

A solution of 120 mg of 6-methylbicyclo[4.2.0]oct-2-en-7-one oxime, prepared as shown in Preparation 19, in 4 ml of levulinic acid/1N hydrochloric acid (9/1) was stirred at room temperature for 48 hours. The mixture was poured into water and extracted with hexane. The combined hexane extracts were washed with saturated sodium bicarbonate, brine and dried over anhydrous sodium sulfate. Solvent was carefully removed under reduced pressure, and the residue chromatographed on silica gel, eluting with 10% ethyl acetate in hexane, to give 6-methylbicyclo[4.2.0]oct-2-en-7-one, the compound of formula (8).

Provenance & Evidence