4-Chloro-2-fluorobenzene-1-sulfonyl chloride → 3-[(4-chloro-2-{[(4-chloro-2-fluorophenyl)sulfonyl]amino}phenyl)thio]-N,N-dimethylpropanamide

HRID 70365Notes

Reaction equation

HRID 70365 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[S:9][CH2:10][CH2:11][C:12]([N:14]([CH3:16])[CH3:15])=[O:13].[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([S:24](Cl)(=[O:26])=[O:25])=[C:20]([F:28])[CH:19]=1>N1C=CC=CC=1>[Cl:8][C:6]1[CH:5]=[CH:4][C:3]([S:9][CH2:10][CH2:11][C:12]([N:14]([CH3:15])[CH3:16])=[O:13])=[C:2]([NH:1][S:24]([C:21]2[CH:22]=[CH:23][C:18]([Cl:17])=[CH:19][C:20]=2[F:28])(=[O:26])=[O:25])[CH:7]=1

Participants

4

Reactant 2

HCID 27788604-Chloro-2-fluorobenzene-1-sulfonyl chlorideHCID 609618703-((2-amino-4-chlorophenyl)thio)-N,N-dimethylpropanamide

Product 1

HCID 679724583-[(4-chloro-2-{[(4-chloro-2-fluorophenyl)sulfonyl]amino}phenyl)thio]-N,N-dimethylpropanamideYield 75%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Following General Procedure B, the title compound (476 mg, 75%) was prepared from 3-((2-amino-4-chlorophenyl)thio)-N,N-dimethylpropanamide (364 mg, 1.42 mmol) and 4-chloro-2-fluorobenzene-1-sulfonyl chloride (325 mg, 1.42 mmol) in pyridine (5 ml).

Sources & evidence

ORD record
ord-4881db47e38247158e749d9a589c5298
Source dataset
uspto-grants-2014_09
Patent number
US08822530B2

Reaction notes

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