Sulfuric Acid → HCID 85552580, compound

HRID 703670Notes

Reaction equation

HRID 703670 reaction equation
[C:1]([C:5]([C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1)=O)([CH3:4])([CH3:3])[CH3:2].[CH3:14][NH:15][NH2:16].S(=O)(=O)(O)O>C(O)C>[CH3:14][NH:15][N:16]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=1

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 6061MethylhydrazineHCID 111380501-(4-Chlorophenyl)-2,2-dimethylpropan-1-one

Product 1

HCID 85552580HCID 85552580, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

29.5 g ofg 4-chlorophenyl tert.-butyl ketone (0.15 mol) in 750 ml ethanol was heated under reflux with an excess (118 ml) of methl hydrazine and 3 ml of concentrated sulphuric acid for 4.5 hours. It was concentrated almost to dryness and the added to water. After extraction with methylene chloride and then drying and concentrating the extract in vacuo, there was obtained an oil which eventually crystallised. The resulting crude product used immediately.

Workup

  1. concentrationIt was concentrated almost to dryness
  2. additionthe added to water
  3. extractionAfter extraction with methylene chloride
  4. customdrying
  5. concentrationconcentrating the
  6. extractionextract in vacuo
  7. customthere was obtained an oil which
  8. customeventually crystallised

Sources & evidence

ORD record
ord-beebd25ad6274fa18fe8c1bdf83185db
Source dataset
uspto-grants-1991_01
Patent number
US04983755

Reaction notes

Loading…