反应详情

3 g of a diastereomer mixture of tetrahydro-3-hexyl-4-hydroxy-(R)-6-undecyl-2H-pyran-2-one are dissolved in 300 ml of acetone. 3 ml of Jones' reagent are added dropwise while stirring in such a manner that the temperature does not exceed 25° C. After 3 hours the reaction mixture is poured into 700 ml of H2O. The lactone Precipitates out and is filtered off. After recrystallization in ether/n-hexane there are obtained 1.7 g of tetrahydro-3-hexyl-4-oxo-(R)-6-undecyl-2H-pyran-2-one, m.p. 112.5°-113.5° C.

1. customdoes not exceed 25° C
2. customThe lactone Precipitates out and
3. filtrationis filtered off
4. customAfter recrystallization in ether/n-hexane there